The story takes place in New York City, where a dormant Soviet space station crashes into a subway tunnel. This unexpected event releases a horde of genetically mutated spiders, which quickly begin to wreak havoc on the city. Our main protagonist is Col. John Murphy (played by Patrick Muldoon), an elite soldier who is called in to lead the mission to stop the spiders. Sydney Sweeney plays his daughter, Emily, who becomes entangled in the dangerous situation. Christa Campbell portrays Rachel Cole, a subway supervisor who finds herself fighting for survival. William Hope takes on the role of Dr. Darnoff, a scientist with knowledge of the spiders’ origins. As the spiders begin to multiply and grow, Col. Murphy and his team must navigate the treacherous underground tunnels to eliminate the threat. Along the way, they encounter numerous challenges and face the constant danger of being overpowered by the spiders.